Prospects for the Use of NGAL and KIM-1 for the Diagnosis of Acute Kidney Injury in Patients Receiving Antibacterial Therapy

The developers of Clinical Practice Guidelines for Acute Kidney Injury titled Initiative to Improve Global Disease Outcomes (KDIGO) point at the need new biomarkers diagnosis acute kidney injury (AKI). objective: study and evaluate diagnostic significance levels neutrophil gelatinase-associated lipocalin (NGAL) molecule-1 (KIM-1) in patients with AKI early postoperative period when antibiotic therapy is used. Subjects Methods. frequency was assessed 276 during after antibacterial drugs had been prescribed. Serum KIM-1 NGAL, glomerular filtration rate (GFR), creatinine, protein urine were tested before start therapy, 24–48 hours, – additionally 72–96 hours. normal initial renal excretory function registered only 36 (13.04%). majority (242 patients, 86.96%) diagnosed chronic disease various stages. Results. NGAL higher group versus preserved function. However, a statistically significant increase level found stages 3A 3B CKD groups 1 2 CKD. second important observation that comorbid pathology led high incidence used 35.86% (30–42%; 95%CI). Conclusion. relationship (GFR) presence proteinuria as indicators impaired suggests reflect state Based on this observation, it should be accepted can markers receiving therapy. prescription surgical dysfunction leads incidence. Elevated their involvement reparation process.